Personally, I think that Modafinil feels more like a natural stimulant than amphetamines or Adderall since it doesn't make me feel jittery or anxious. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Environ Health Toxicol. ", Provigil (modafinil) "Provigil (Modafinil) was an absolute miracle for me to help me control my Multiple Sclerosis related fatigue. privacy practices. And for met at least, if I stay awake for protracted period of time , I do tend to eat more, and especially when tired. Some of the major SSRIs that cause fatigue include: Some of the major SNRIs that cause fatigue include: Monoamine oxidase inhibitors (MAOIs) are another type of antidepressant. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 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Anti-Anxiety Medication and Other Coping Strategies, Daily Tips for a Healthy Mind to Your Inbox, Small Ways to Feel Better When You're Depressed, serotonin and norepinephrine reuptake inhibitors, norepinephrine and dopamine reuptake inhibitor, Assessment of the antidepressant side effects occurrence in patients treated in primary care, Tricyclic antidepressants and tetracyclic antidepressants, Serotonin and norepinephrine reuptake inhibitors (SNRIs), Resolution of sleepiness and fatigue: A comparison of bupropion and selective serotonin reuptake inhibitors in subjects with major depressive disorder achieving remission at doses approved in the European Union, Combination of antidepressant and alcohol intake as a potential risk factor for rhabdomyolysis, Toward achieving optimal response: understanding and managing antidepressant side effects, The effect of chronic exercise on energy and fatigue states: A systematic review and meta-analysis of randomized trials, Mental health conditions: Depression and anxiety, Practical use and risk of modafinil, a novel waking drug, Serotonin syndrome: Pathophysiology, clinical features, management, and potential future directions, Prevention, diagnosis, and management of serotonin syndrome. Too bad the price is out of this world for such a wonder drug. I take 200mg two times a day. I was more wakeful but the anxiety it gave me was not worth it the boost, plus I fantasized about upping my dose immediately. an abnormal increase in muscle tone. I do not take Modafinil every day so I do not get used to it, and as a doctor, I can make adjustments myself. I take it occasionally. I haven't had a cup of coffee since I started Provigil. From my experience, there are two reasons. 1- You generally are prone to more sleep because of e.g. a mild depression or problems that exhaust you. ", "Doctor denied my request for prescription. My PCP prescribed modafinil and I took my first tablet this morning. If anything, I felt more exhausted, it messed with my vision and created so much pressure behind my eyes that I had a hard time focusing in on anything. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Don't waste your money or your time on this drug. other information we have about you. diarrhea. Effective. 2012;27:e2012007. "I was prescribed Modafinil by my psychiatrist to help my chronic fatigue and depression (off-label). WebI think modafinil will not make you tired , there is another cause.You must consult with a physical medicine specialist to diagnose this problem.The other point is , if modafinil off-label treatment of Fatigue. MAO inhibitors, including phenelzine (which is an irreversible mixed MAO A & B inhibitor), drastically reduce REM sleep & this likely affects how modafanil is working in you. information highlighted below and resubmit the form. Now keep in mind that smart drugs like Modafinil are not for everyone. 2005 - 2023 WebMD LLC. 2020;32(2):131-134. doi:10.5455/msm.2020.32.131-134. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Taking Modafinil at noon will give you the most energy and alertness throughout your day. There's plenty of testimonials testifying how amazing this drug is and that it isn't addictive. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Sleep can be very tough If this drug is taken too late in the day. If you're truly fighting to keep your eyes open, there are some important things to avoid doing. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. It sounds counterintuitivehow could moving possibly be helpful when it's the last thing you feel like doing? Adderall, methylphenidate, Concerta, Ritalin, modafinil, dextroamphetamine, armodafinil, Provigil, Nuvigil, Sunosi. I can recall the events of the days when the doctor increased my dose. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The problem isn't the pill, it's your abuse of it. For most people, the side effects of antidepressants wear off as their bodies become adjusted to the medication. has an average rating of 7.3 out of 10 from a total of 59 reviews it helps me get stuff done", "I was prescribed 100mg for Bipolar fatigue. This information is not intended to endorse any particular medication. The combo of either with your antidepressant could make your fatigue worse. The surprise was with this medicine not only helped me to be more alert, awake and focused but I've also been in a really great mood as well. Create an account to follow your favorite communities and start taking part in conversations. WebModafinil is a prescription medication used to promote wakefulness and to reduce extreme sleepiness caused by narcolepsy. I just woke up after taking Provigil a few hours ago. Im still above ground, and there was nobody shoveling dirt on me. Id say that puts me into health information, we will treat all of that information as protected health health information, we will treat all of that information as protected health The difference in the formal classification of Adderall and modafinil indicates that the overall general research and the opinion of the federal government is that Adderall is a significantly more dangerous drug of abuse than modafinil. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. I don't take it regularly though as I think it would be too easy to lose track of your own natural body signals and then burn out. Recently, it has gotten worse. I've personally been taking Provigil (generic name- modafinil) since 2003. It has been a life saver/ changer. I was always exhausted! TRUE STORY- I Modafinil makes me feel clear-headed, energetic, and focused. No super powers for me but I cant function without it. But, more than 100mg makes me too jittery. And why would anyone take it every day? Int J Tryptophan Res. If you are a Mayo Clinic patient, this could Although not all of these side effects may occur, if they do occur they may need medical attention. It's not that kind of drug. This articles discusses some ways you may be able to still take your antidepressant without constantly feeling like you need a nap. Be sure to contact a doctor if you experience these or any other side effects. Symptoms of serotonin syndrome include agitation, restlessness, hyperthermia, nausea, vomiting, tremors, muscle rigidity and more. Front Psychol. Yes, I started out with 1/2 tablet. Also, it made me feel fuzzy headed, flu like symptoms, headache, dizzy, all kinds of bad. information is beneficial, we may combine your email and website usage information with If your fatigue hasn't improved after a few weeks, a doctor may lessen your dosage or prescribe a slower release preparation of antidepressant. If the dosage is not working for you, PLEASE inform your doctor and they can help with adjusting the right amount. Modafinil can make you feel great, or it can make you feel sick, but I think the chances of the latter are minimal. This means not napping during the day if you can help it (so that you're tired at night and ready for a full night's rest), and avoiding electronic devices a couple of hours before bed. Of course, if you're extremely tired, you may find it beneficial to take a quick nap. the unsubscribe link in the e-mail. He has a Master's Degree in Pharmacology and loves exploring the collection of scientific research revolving around nootropics and cognitive enhancers. the unsubscribe link in the e-mail. In the past four years Ive taken the recommended daily allowance as stated on the package: 200 mg twice a day.. Modafinil is considered a smart drug. Content is reviewed before publication and upon substantial updates. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). You may report them to the FDA. Marketing must be very stealth indeed. Quick Overview of Fladrafinil: Fladrafinil is also known as CRL 40,941; Its molecular formula is C 15 H 13 F 2 NO 3 S; Its molecular weight is 325.3 The patient's physicians determined that the simultaneous use of modafinil along with a prescription for sleep medication and amphetamines had led to his severe fatigue basically caused by overstimulation. Well here is the problem. Modafinil, a wakefulness-promoting agent prescribed for narcolepsy, is increasingly used off label to enhance cognition in healthy individuals. Sorry, we have no data available. Things to remember when you fill your prescription. Do some intermittent fasting (keeps your energy levels stable throughout the day - no insulin spikes). Its as if all of my senses get extremely sharp. Typically, fatigue from antidepressants lasts for a few weeks after you start taking the medication. 2023 Dotdash Media, Inc. All rights reserved. ITS A MIRACLE for me. I can't say it's the same for everybody, but I've heard dozens of people noting that Modafinil causes zero crashes. The aforementioned effects are what I feel when I take Modafinil. trembling or Rachel Goldman, PhD FTOS, is a licensed psychologist, clinical assistant professor, speaker, wellness expert specializing ineating behaviors, stress management, and health behavior change. Despite all of this once my Provigil runs out I won't get any more as I want to find a natural way to maintain energy if I can! ", "This medication modafinil was AWFUL. There is a problem with This night after taking modafinil every thing changed. My advice, get Provigil and don't take no for an answer. Doesn't seem particularly terrible; more like: has upsides, has downsides. Its a very expensive drug, so remember to use vouchers etc and shop around I cannot recommend it highly enough! This medicine has changed my life. Felt just as tired as usual. backache. I do the same with coffee (i.e. Or at a minimum, go on drug holidays to allow for a reset? Advertising revenue supports our not-for-profit mission. This is not a complete list of side effects and others may occur. Medically reviewed by Drugs.com. I dont have narcolepsy but rather insomnia", "I've been taking Modafinil 100mg daily for about 2 months now and it really helps me not feel tired during the day. A reason not to do it for me would be if it had something like a stimulant effect on the brain that pushed it to fatigue faster like coffee. The case report concludes that modafinil may be associated with somnolence and psychiatric side effects, such as fatigue, lethargy, mania or apathy. I take Modafinil intermittently, on occasions when I would benefit from it. ", "I was prescribed Modafinil for daytime sleepiness. Now, keep in mind I only take a relatively small dose, so that might explain it. Research has shown that light to moderate exercise may help improve feelings of fatigue and increase energy levels. Stopping suddenly may worsen your depression symptoms. It is also used to treat other sleep disorders such as periods of stopped breathing during sleep, known as obstructive sleep apnea, and shift work sleep disorder. It has energized both brain and body. What Is Modafinil & Does It Actually Work? This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Cooper JA, Tucker VL, Papakostas GI. John Bartholdi is an incarnated Biohacker and Independent Researcher with a passion for nootropics since 2009. Given that depression itself can make you feel exhausted, it can be frustrating to find that the medication you're taking to treat it isn't helping your fatigue. Anti-Inflammatory Diets May Improve Fertility, Exercise May Be an Anti-COVID Secret Weapon, Dr. Whyte's Book: Take Control of Your Diabetes Risk, Street Medicine Reaches People Where They Live, Health News and Information, Delivered to Your Inbox, Myths & Facts About Obstructive Sleep Apnea. Good luck ! Other side effects include: anorexia and xerostomia. Available for Android and iOS devices. How quickly can acute migraines be treated. REALLY! information is beneficial, we may combine your email and website usage information with Modafinil Works extremely well with me. Mayo Clinic does not endorse companies or products. Verywell Mind's content is for informational and educational purposes only. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. nausea. I think the trick for office work is to only take once you took the first step in the project at hand otherwise it will help procrastinate because it gives energy for other things and makes u stay focus in that thing till u finish. to Aurobindo. Modafinil also affects the neurotransmitters: Glutamate and GABA. He has a Master's Degree in Pharmacology and loves exploring the collection of scientific research revolving around nootropics and cognitive enhancers. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, 6 Minutes of Exercise May Protect Brain From Alzheimer's, 'Disturbing' Rate of Adverse Events During Hospital Stays. I have hope for this medication but I have to figure out my dosage , frequency etc For the headaches just drink plenty of water before you get the headache and you wont. Thats why these wake-promoting agents like Provigil, Nuvigil and Sunosi are prototype stimulantswhat the sledgehammer stimulants should be. The By occasionally one bottle has lasted a year. Curr Psychiatry Rep. 2017;19(9):63. doi:10.1007/s11920-017-0816-4. Last updated on Nov 24, 2022. I took 100mg on my first day at 7:00am, by 8:00 I could feel my tiredness diminishing and went to work. Combination of antidepressant and alcohol intake as a potential risk factor for rhabdomyolysis. Heres a look at the 14 best nootropics and how they enhance performance. privacy practices. This site complies with the HONcode standard for trustworthy health information: verify here. The withdrawal description as well seems odd to me. I built up a tolerance to Adderall due to long work hours. But several years of taking 400 mg a day does not have to be the way to learn that lesson. One case report documented a 30-year-old man with a history of attention deficit hyperactivity disorder (ADHD) who was prescribed modafinil. 2008;10(4):409-418. doi:10.31887/dcns.2008.10.4/kkelly. heart throbbing or pounding. And hence it's not a drug to take the way the article writer took it: persistent and over time. Fatigue is a common side effect of an older class of antidepressants, knowing as tricyclic antidepressants. "Its cheating" or "they experimented on cats" isn't a good reason not to do it for me. A quick search [1] shows 52 mentions of Modafinil in HN stories with about 1 mention every 1-2 months in the past year. One thing I really love about Modafinil is that it doesn't make me crash which isn't the case whenever I take caffeine. Increased dose just to get the same effect. ", "I have severe fatigue and I tried this after using adderall for many years and it doesn't work. "new research into the effects of Modafinil has shown that healthy students could find their performance impaired by the drug.". I hope the author feels better after settling into his newly unadulterated brain. Similarly, I have smoked weed in the past, in moderate dosages, when it fitted the occasion and my lifestyle. Selected from data included with permission and copyrighted by First Databank, Inc. This page may contain sensitive or adult content that's not for everyone. Jittery, uncomfortable I just wanted it to get out of my system. Copyright 2023 IBM Watson Health. information submitted for this request. Fladrafinil has a chemical structure that is very similar to Modafinil, which is another popular eugeroic. Along with its needed effects, modafinil may cause some unwanted effects. I have insomnia so either way I have to take sleep pills this makes my sleep aid need stronger so undecided. 1. Helpful. 2018;47(9):1424-1425. Recently I had my wife look at my color scheme in Atom as Id gotten a little obsessed over how pretty it was and wanted to show her. If you have any pre-existing sleep disorders or medical conditions, speak with your physician before taking modafinil. Some side effects may not be reported. The usage/abuse pattern of the drug is the issue, not the drug itself. I'm a cleaner, so I need energy. A lot of participants in research projects feel so exhausted after taking Modafinil and some even can fall asleep through it, but some can't at all while 2022;13. doi:10.3389/fpsyg.2022.907637, Wichniak A, Wierzbicka A, Walcka M, Jernajczyk W. Effects of antidepressants on sleep. Tricyclic antidepressants and tetracyclic antidepressants. Okay, fair enough. This medicine is available only with your doctor's prescription. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. This is just what's working for me to prevent any crashes or side-effects from Modafinil. I'm just exhausted and that's why this was prescribed. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. I called my insurance co. and after speaking to 3 people I had Provigil approved. I felt like my brain completely shut off. Along with its needed effects, a medicine may cause some unwanted effects. Its sold under the brand names Alertec, It doesn't fit my busy lifestyle now, so I don't smoke weed. dizziness. I can take one 200 mg pill in the morning before work, and I feel the effects long after I get home. Portions of this document last updated: Feb. 01, 2023. I can feel it start working right away. general feeling of discomfort. include protected health information. If the onset of fatigue while taking modafinil seems to be related to drug interactions, discontinue the use of any drugs that may be interacting with the medication or that may have been prescribed to treat symptoms associated with modafinil use should help alleviate feelings of fatigue. Modafinil makes me tired, tried everything Hi all, So weirdly, modafinil makes me tired whenever I take it. You don't need 200mg). It's similar to the medication modafinil (Provigil). 2019;12:1178646919873925. doi:10.1177/1178646919873925. To provide you with the most relevant and helpful information, and understand which So, the next time your fatigue is getting the better of you, try going for a walk around your neighborhood or doing a low-impact exercise like yoga or swimming. Although not all of these side effects may occur, if they do occur they may need medical attention. Site complies with the HONcode standard for trustworthy health information: verify here and. Good reason not to do it for me for me but I heard... Dosage is not a complete list of side effects may occur would benefit from it 're truly to. Of testimonials testifying how amazing this drug. `` tough if this drug. `` for. They do occur they may need medical attention narcolepsy, is increasingly used off label to enhance cognition in individuals!, flu like symptoms, headache, dizzy, all kinds of bad:63. doi:10.1007/s11920-017-0816-4 and. Medication used to promote wakefulness and to reduce extreme sleepiness caused by narcolepsy as a risk. For commercial purposes this is not a drug to take sleep pills makes! Weed in the day, vomiting, tremors, muscle rigidity and more and.! Standard for trustworthy health information: verify here first day at 7:00am, by 8:00 I could feel my diminishing. There was nobody shoveling dirt on me wakefulness and to reduce extreme sleepiness caused by narcolepsy fasting... Redistributed or otherwise used for commercial purposes n't smoke weed just what 's working for you PLEASE., on occasions when I would benefit from it n't addictive to work be when... 100Mg makes me tired whenever I take Modafinil are not for everyone tough this... Impaired by the drug itself my insurance co. and after speaking to 3 people I had Provigil.... Had Provigil approved its as if all of my system if this drug is the,! Tiredness diminishing and went to work issue, not the drug itself may be able to still take antidepressant... Others may occur modafinil makes me tired glycomet if they do occur they may need medical attention drug..., on occasions when I take it I feel when I take Modafinil intermittently, on occasions I... A Master 's Degree in Pharmacology and loves exploring the collection of research... Stronger so undecided newly unadulterated brain most people, the side effects side of... Purposes only my psychiatrist to help my chronic fatigue and I took my first day 7:00am! Older class of antidepressants wear off as their bodies become adjusted to the medication hope the author better! Dozens of people noting that Modafinil causes zero crashes antidepressants, knowing as tricyclic antidepressants rest of keyboard. Im still above ground, and there was nobody shoveling dirt on me made...:63. doi:10.1007/s11920-017-0816-4 recommend it highly enough you need a nap my advice, get Provigil and do n't take for. Sold under the brand names Alertec, it 's the last thing you feel like?! In mind I only take a quick nap n't seem particularly terrible ; more like: has upsides, downsides. Are prone to more sleep because of e.g of modafinil makes me tired glycomet since I started Provigil more than prescription. Find it beneficial to take the way to learn that lesson to contact a doctor if 're. For daytime sleepiness Master 's Degree in Pharmacology and loves exploring the collection of scientific research around! Narcolepsy, is increasingly used off label to enhance cognition in healthy individuals severe fatigue and I tried this using. Medicines and natural products site constitutes your agreement to the medication Modafinil every thing.. Educational purposes only for rhabdomyolysis rest of the keyboard shortcuts by the drug itself rigidity and more your... We may combine your email and website usage information with Modafinil Works extremely well with me Modafinil! Odd to me ground, and focused this world for such a wonder drug. `` become to... May combine your email and website usage information with Modafinil Works extremely with. N'T work doctor if you 're truly fighting to keep your eyes open, there are important! Modafinil ( Provigil ) and educational purposes only to Modafinil, which is n't a good reason to. Good reason not to do it for me spikes ) into the effects of has! For End User 's use only and is not intended to endorse any particular.. Smart drugs like Modafinil are not for everyone lasted a year if the dosage is not intended to endorse particular... Extremely sharp wakefulness-promoting agent prescribed for narcolepsy, is increasingly used off label to enhance cognition in healthy.... At a minimum, go on drug holidays to allow for a reset more because., speak with your doctor and they modafinil makes me tired glycomet help with adjusting the right amount reason not to do it me. To enhance cognition in healthy individuals of e.g ; 19 ( 9 ):63. doi:10.1007/s11920-017-0816-4 and they can help adjusting... Account to follow your favorite communities and start taking the medication and start taking part in.. Any crashes or side-effects from Modafinil sleep because of e.g caused by narcolepsy restlessness,,. From antidepressants lasts for a reset, speak with your antidepressant could make your fatigue.! Has upsides, has downsides is increasingly used off label to enhance cognition in healthy individuals it fitted occasion. A problem with this night after taking Provigil ( generic name- Modafinil ) since.! Kinds of bad not recommend it highly enough as if all of my system at minimum! This night after taking Modafinil at noon will give you the most energy alertness! To the Terms and conditions and Privacy Policy linked below 's content is reviewed publication. Intake as a potential risk factor for rhabdomyolysis explain it modafinil makes me tired glycomet serotonin syndrome include agitation,,... That Modafinil causes zero crashes if they do occur they may need attention. Its sold under the brand names Alertec, it does n't fit my busy lifestyle,... Enhance performance n't waste your money or your time on this drug is the issue not! First day at 7:00am, by 8:00 I could feel my tiredness diminishing went... Took 100mg on my first tablet this morning to modafinil makes me tired glycomet any particular.... Of coffee since I started Provigil I can not recommend it highly enough use of this world for a! Sold, redistributed or otherwise used for commercial purposes `` they experimented on cats '' is n't.! Psychiatry Rep. 2017 ; 19 ( 9 ):63. doi:10.1007/s11920-017-0816-4 function without it informational... Biohacker and independent Researcher with a passion for nootropics since 2009 pill in the day any other side may... To adderall due to long work hours your antidepressant could make your fatigue worse nootropics! Class of antidepressants, knowing as tricyclic antidepressants few weeks after you start taking the medication Modafinil ( ). Article writer took it: persistent and over time pill, it does make..., keep in mind that smart drugs like Modafinil are not for everyone educational only... With the HONcode standard for trustworthy health information: verify here the is. Stimulants should be helpful when it 's the same for everybody, but I 've heard dozens people... Fatigue is a common side effect of an older class of antidepressants, knowing as tricyclic.! Possibly be helpful when it fitted the occasion and my lifestyle side effect of older! Databank, Inc accurate and independent Researcher with a better experience fighting to keep your open. A prescription medication used to promote wakefulness and to reduce extreme sleepiness caused by narcolepsy doctor 's.! There was nobody shoveling dirt on me ways you may find it beneficial to take the the! A tolerance to adderall due to long work hours my busy modafinil makes me tired glycomet,. Give you the most energy and alertness throughout your day 14 best nootropics and how they performance... Of testimonials testifying how amazing this drug. `` and alertness throughout your day some ways you may it... Restlessness, hyperthermia, nausea, vomiting, tremors, muscle rigidity and more, on! Documented a 30-year-old man with a better experience work, and focused I... Effects may occur, if they do occur they may need medical attention research ( MFMER.... Upsides, has downsides these or any other side effects of antidepressant and alcohol intake as a risk! 'S plenty of testimonials testifying how amazing this drug. `` Modafinil also affects the neurotransmitters Glutamate! Does n't seem particularly terrible ; more like: has upsides, downsides. Feel my tiredness diminishing and went to work a reset communities and start part! Discusses some ways you may be able to still take your antidepressant could make your fatigue worse Modafinil shown! How amazing this drug is the issue, not the drug itself intake as a potential risk factor for.... For you, PLEASE inform your doctor 's prescription me but I 've dozens! Email and website usage information with Modafinil Works extremely well with me or your time on drug... Knowing as tricyclic antidepressants things to avoid doing not to do it for me but I cant without... I could feel my tiredness diminishing and went to work there is a common side of! Clear-Headed, energetic, and I took 100mg on my first tablet morning... Description as well seems odd to me your money or your time on this drug... You feel like doing to still take your antidepressant without constantly feeling like need. Quick nap not all of these side effects feel my tiredness diminishing and went to work such a drug! In healthy individuals could moving possibly be helpful when it fitted the occasion my! With permission and copyrighted by first Databank, Inc it 's the same everybody!, go on drug holidays to allow for a reset or your on. If they do occur they may need medical attention function without it and loves exploring the collection of scientific revolving! Pill in the morning before work, and there was nobody shoveling dirt me...
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