?, Soul of the Lost, 4 rooms: Rune of Ehwaz, Rune of Perthro, Black Rune, Soul of Isaac, Soul of Eve, Soul of Eden, Soul of the Forgotten, Soul of Jacob and Esau, 6 rooms: Rune of Dagaz, Soul of Samson, Soul of Azazel, Soul of Apollyon, Soul of Bethany, 12 rooms: Rune of Jera, Soul of Lilith, Soul of the Keeper, Tears have a chance to fire a fungus tear that sticks to enemies. Donation machines become fixed if they were jammed before using the R Key, Isaac now has a chance to fire a fist instead of normal tears, which have a much higher knockback effect and confuse enemies for a few seconds, Enemies that are knocked back will take 10 damage and knock back any enemy they are knocked into, dealing damage to them as well, An active item that allows you to throw an eraser at any enemy, which will kill it and prevent it from appearing for the rest of the run, Enemies that are erased create a puff of smoke instead of spawning, Works on bosses, except it doesn't kill them it just deals 15 damage, Can only be used once per floor - batteries also cannot be used to recharge it to bypass this restriction, The first use will raise it above your head, then by pressing the fire button it will be thrown in that direction, Recharge time: 1 room (Can only be used once per floor), When used, this item will give you +1 Rotten Heart, Rotten Hearts act as red hearts and each one you currently have spawns 2 blue flies upon successfully clearing a room, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Maggy, Enemies now create a soul upon death, which is automatically sucked into the Urn giving it +1 charge. Beyond the womb floor, replaces all coin and key spawns with a random pickup as follows: Bomb - 26.6% chance. Item will only heal the character with which we start the game tank of character. Tears now have a chance to cause enemies to be magnetized, Magnetized enemies attract other enemies, tears (including Isaac's) and enemy projectiles, causing them to be pulled in towards them, Enemy tears that get pulled into other enemies will hurt them, You have a chance to fire a tear that marks enemies red and slow them, Marked enemies will be attacked by other enemies either until it is killed or it kills all the other enemies attacking it, Chance to fire a marking tear scales with your luck stat, This item has a different effect for each character. See the Broken Shovel / Mom's Shovel items for more information on how to unlock, Rotten Hearts fill up a whole container the same as normal red hearts, or the rightmost heart if you're at full health, Every time you clear a room, you'll spawn 2 Blue Flies for each Rotten Heart you currently have, UNLOCK: Unlock this by entering the Corpse floor for the first time, Spawns 2-3 pills, black/bone hearts and/or bombs when picked up, Can spawn in place of a regular sack, including in Shops for 7c, Only one heart can spawn per sack as a maximum, UNLOCK: Unlock this by defeating Mega Satan as Tainted Judas, 48 Hour Energy - Fully recharges your active item and drops 1-2 battery pickups. As players are coming down into the Ruins, there will see a number of Electric Devices. UNLOCK: Unlock this item by defeating Hush as Bethany, At the beginning of each new floor, this item will stab Isaac and reduce your red health down as much as it can without killing you. pill) or picking up the Match Stick trinket, which will burn it off you, *, insect, bug, spider, beetle, grey, gray, brown, While held, this trinket gives Isaac a familiar that shoots piercing tears that deal 3.5 damage, UNLOCK: Unlock this item by beating the Boss Rush with Isaac, At the start of a new floor, you get an eternal heart, UNLOCK: Unlock this item by beating the Dark Room with Maggy, * , the lost item pool, cross, yellow, golden, glow, maggys faith, Items which cost 2 heart containers in a deal with the devil are reduced to only cost 1 heart, UNLOCK: Unlock this item by beating Satan with Judas, * , the lost item pool, tong, red, bloody, lips, judas tongue, Creates a familiar which moves around the room in a similar fashion to The Peeper, shooting tears in the same direction as Isaac, UNLOCK: Unlock this item by beating the Dark Room with Blue Baby, *, dead, baby, blue, ?? The first step to getting the true ending in this new DLC is to collect Knife Piece 1 and 2 in order to assemble the Knife. Taking a Devil deal breaks the cross and prevents the damage up next floor, Taking free pickups such as Black hearts in the Devil room also count, UNLOCK: Unlock this item by defeating The Beast as Judas, When you die, you turn into a ghost with 1/2 a red heart and flying, that is chained to your body for 10 seconds. Item Pool: Item Room, Devil Room, Library, * item room, treasure room, item room pool, devil pool, devil room pool, devil deal, book, brown, blue, monster manuel, manaul, Upon use, the dead sea scrolls gives a random spacebar item effect, An item that can be found in the Angel room. Using it hurts you for half a heart but you'll get 1.2 extra damage for the room you're in. UNLOCK: Unlock this item by defeating The Beast as ??? One exception to this is if you are playing as Lazarus or have Lazarus' Rags - you will respawn in the same room and get the kill, Plan C is 5 times rarer than other items in the same item pool, making it less likely to appear, UNLOCK: Unlock this item by defeating Greedier Mode with Lazarus, Item Pool: Shop, Devil Room, Curse Room, Red Chest, Demon Beggar, When used, the D1 duplicates 1 random pickup in the current room. The official subreddit for Edmund McMillen's Zelda-inspired roguelite, The Binding of Isaac! So I decided to make a quick(ish) guide, mostly for my future self tbh. This allows you to choose between the item that originally spawned and a HP upgrade every time, This effect applies to most items, including those in the shop and devil room. Breakfast = +0.2 shot speed, +1.5 Range. Soul Hearts that are used to charge Spirit Shackles will not be added to your health as normal, UNLOCK: Unlock this item by defeating The Beast as The Forgotten, Taking damage reveals a random room on the minimap, and automatically opens certain doors in the current room. The Binding shop item pool, x, paper, Makes all of Isaac's familiars stronger and bigger, Causes most familiars to deal double damage, Has no effect on most familiars that scale with Isaac's tear damage, * key master pool, key beggar pool, key judgement pool, shop room pool, shop item pool, red, heart, the lost item pool, white, A familiar that follows Isaac and can fire up and charge brimstone shots, exactly how the normal Brimstone item works but with less damage, Each laser deals 3 damage per tick, up to 8 times for a total of 31.5 damage, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, horns, baby, you could find a caves boss in the basement. Brought up on mascot platformers and role-playing games from Japan, Ryan has been passionate about gaming for over two decades. This guide will show a description of how to unlock every achievement in the game. grey, gray, pentagram, Deals 40 damage to everything in the room when used, REPENTANCE - Reduced to 3 room recharge time, UNLOCK: Unlock this item by using 4 XIII - Death cards, Item Pool: Library, Secret Room, Devil Room, * library pool, library room, book room pool, secret room pool, devil pool, devil room pool, This guide will show a description of how to unlock every achievement in the game. arrow, Causes your friendly blue spiders and flies to become bigger and do x2 more damage, Allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5, Fly and spider familiars become stronger similar to BFFS, * shop room pool, shop item pool, blue, fat, Two items now spawn after beating a boss fight and the boss rush, however only one can be taken, The additional item will pick from the Boss Item Pool, Unlocked by donating to the donation machine in the shop, UNLOCK: Unlock this item by donating 50 pennies to the Shop, * shop room pool, shop item pool, white, question mark, square, theres options, * shop room pool, shop item pool, purple, paper, ticket, Isaac can now hold 2 cards or runes at once. You have to die in a Sacrifice Room while holding the Missing Poster. She can't use blue or black hearts. as Bethany, Gives you a random syringe effect every room, The effect can be The Virus, Roid Rage, Speed Ball, Experimental Treatment, Synthoil, Euthanasia or Growth Hormones, Placed bombs explode after 0.66 seconds instead of the usual 1.5 seconds, This was called Exploded Firecracker in Antibirth, Farts produced by Isaac or familiars will be twice as large, Chance for enemies to burn when entering a room, The chance for this effect to activate is effected by your Luck stat, This includes key blocks and golden chests, Pickups left on current floor will appear in the starting room of the next floor, up to a maximum of 4 pickups, Active items will be rerolled upon using them, Using with Book of Virtues will only reroll the item the book is holding, Has no effect with Notched Axe due to how its durability works, UNLOCK: Unlock this trinket by defeating Mother as Eden, Random luck-based tear effects have an extra chance of occurring, The additional chance is effectively +3 Luck Up, Picking up red hearts now has a high chance to spawn 1-4 blue attack spiders, instead of giving you health back, This effect also works while fully healed, giving a guaranteed chance of getting spiders, While missing any red health the chance for spiders is less, Works for characters that don't use red health, which always gives you spiders, Hearts in Shops can be converted into spiders for free, Gives your familiars improved rate of fire while held, In Antibirth this trinket was called Song of the Siren, UNLOCK: Unlock this trinket by bombing the skull left by The Siren boss after her death, While held at the start of each floor, this trinket spawns four wisp familiar orbitals around Isaac, These wisps are the same as the ones created by the Book of Virtues item, UNLOCK: Unlock this trinket by beating the Boss Rush as Bethany, Your active item no longer gains charges, but battery drops become much more common, UNLOCK: Unlock this trinket by blowing up 10 Battery Beggars, Tears that miss enemies will redirect themselves and travel 90 degrees towards enemies, Tears must be roughly 2 tiles or closer to activate this effect, +10 Luck while held, but the trinket is destroyed when damage is taken, Blood donation machines, Curse Rooms and Sacrifice Rooms wont destroy it, Taking a hit and activating Holy Mantle won't destroy it, Can be dropped in order to avoid breaking it, This trinket is automatically given to you after clearing 3 bosses without taking damage, Treasure Rooms are replaced with Red Treasure Rooms, which contain a deal with the devil in place of a regular item pedestal, If an item room has not yet been entered, it can be transformed to either a regular or Red Treasure Room by picking up or dropping this trinket before entering, Does not affect the mirrored treasure room in Downpour II, UNLOCK: Unlock this trinket by defeating Mother as Azazel, Every time you pick up a coin, you have a small chance to gain 1 bar of charge on your active item, The chance for this effect to happen is 1/6th of the value of the coin picked up, Can only activate once per coin collected, In Antibirth this trinket was called Electric Penny, UNLOCK: Unlock this trinket by donating to a battery beggar until he pays out with an item 5 times, While held, your familiars will now orbit around Isaac instead of following behind him, Activates your active item just before damage would be taken, It doesn't activate for free - the charges are used up as normal if this effect activates. 
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